effect of nitric oxide on skin blood flow of intact and morphine- dependent rats
نویسندگان
چکیده
introduction: the relation between morphine and nitric oxide release has been shown. due to important role of nitric oxide in regulation of skin blood flow, the aim of this study was to investigate the effect of nitric oxide synthase inhibitor (l-name) and nitric oxide synthesis precursor (l-arginine) on skin blood flow of intact and morphine-dependent rats. methods: skin blood flow of hind paw was measured using laser doppler flowmetry (ldf) technique. animals became morphine dependent by a well established protocol. results: subcutaneous injection of l-arginine (10 or 20 mg/kg) respectively increased skin blood flow by 39% and 64% in intact rats and by 37% and 65% in morphine-dependent rats. there was no significant difference between blood flow in intact and morphine-dependent rats. l-name (1 or 5 mg/kg) diminished skin blood flow of intact rats by 35% and 58.7% and skin blood flow of morphine-dependent rats by 29.1% and 60.5%, respectively. there was no significant difference between these two groups. the effect of l-arginine was abolished by pretreatment with l-name in morphine-dependent as well as intact groups. conclusion: our results suggest that changes in the level of nitric oxide, cause the same skin blood flow alterations in both morphine-dependent and intact rats. more experiments are needed to elucidate the level of nitric oxide release in skin vascular system following dependency.
منابع مشابه
Effect of nitric oxide on skin blood flow of intact and morphine- dependent rats
Introduction: The relation between morphine and nitric oxide release has been shown. Due to important role of nitric oxide in regulation of skin blood flow, the aim of this study was to investigate the effect of nitric oxide synthase inhibitor (L-NAME) and nitric oxide synthesis precursor (L-arginine) on skin blood flow of intact and morphine-dependent rats. Methods: Skin blood flow of hind pa...
متن کاملAssessment of the effect of nitric oxide within hippocampal CA1 area on spatial learning and memory in morphine dependent rats
Introduction: There are evidences showing the role of nitric oxide in the opiate reward properties. The role of nitric oxide signaling pathway as an intracellular mechanism on augmentation of long term potentiation in hippocampal CA1 area of rats is also confirmed. It has been also reported that oral morphine dependence facilitates formation of spatial learning and memory via activation of N...
متن کاملthe effect of explicit teaching of metacognitive vocabulary learning strategies on recall and retention of idioms
چکیده ندارد.
15 صفحه اولthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولeffect of seed priming and irrigation regimes on yield,yield components and quality of safflowers cultivars
این مطالعه در سال 1386-87 در آزمایشگاه و مزرعه پژوهشی دانشگاه صنعتی اصفهان به منظور تعیین مناسب ترین تیمار بذری و ارزیابی اثر پرایمینگ بر روی سه رقم گلرنگ تحت سه رژیم آبیاری انجام گرفت. برخی از مطالعات اثرات سودمند پرایمینگ بذر را بر روی گیاهان مختلف بررسی کرده اند اما در حال حاضر اطلاعات کمی در مورد خصوصیات مربوط به جوانه زنی، مراحل نموی، عملکرد و خصوصیات کمی و کیفی بذور تیمار شده ژنوتیپ های م...
assessment of the effect of nitric oxide within hippocampal ca1 area on spatial learning and memory in morphine dependent rats
introduction: there are evidences showing the role of nitric oxide in the opiate reward properties. the role of nitric oxide signaling pathway as an intracellular mechanism on augmentation of long term potentiation in hippocampal ca1 area of rats is also confirmed. it has been also reported that oral morphine dependence facilitates formation of spatial learning and memory via activation of nmda...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
physiology and pharmacologyجلد ۱۰، شماره ۴، صفحات ۲۶۷-۲۷۴
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023